Bronchial asthma – prediction

Using data from about 2,500 Canadian children, the researchers assessed the presence of atopic dermatitis and allergic sensitization in children as young as one year old. When the children were three years old, the researchers conducted a clinical evaluation for the presence of bronchial asthma, allergic rhinitis, food allergies, and eczema.
One-year-old children who have eczema or atopic dermatitis and are allergic to an allergen are seven times more likely than other children to develop asthma and food allergies by the age of three, the researchers concluded. This work will help doctors better predict which children are likely to develop asthma and allergies. It has long been known that infants with eczema or atopic dermatitis are more likely to develop asthma and allergic rhinitis later in life, a phenomenon known as the “atopic march.” But it was difficult to predict which children with eczema would develop these problems in the future. It was found that having only eczema, without sensitivity to allergens, does not significantly increase the risk of developing asthma in children. The results of the study help to understand the association of atopic dermatitis and early allergic sensitization with the risk of asthma and food allergies and show that, in combination, they pose a significant risk of future allergic diseases. Two thousand three hundred children participated in the study. The collected data made it possible to assess the presence of eczema and sensitivity to allergens at the age of one year. When the children were three years old, the researchers conducted a clinical evaluation to determine the presence of asthma, allergic rhinitis, food allergies, and atopic dermatitis. The combined effect of eczema and allergic sensitization has been found to be greater than the sum of their individual effects on both asthma risk and food allergy.
There are certain genetic variants known to be risk factors for developing allergies, but genotyping is not widely used in clinical practice, and this study offers healthcare professionals an alternative method for identifying children at risk. The findings are based on another study that found that children who avoid cow’s milk products, eggs and peanuts during the first year of life are at increased risk of allergic sensitization to these products later. As the authors noted, much of what happens to us later is related to the risks we face in early childhood.

event_note March 11, 2022

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