Euphyllin is a bronchodilator related to xanthines. It is based on theophylline. This substance relaxes smooth muscles, relieves spasms and dilates the bronchi. Euphyllin is a phosphodiesterase inhibitor. Despite the relative safety and wide spectrum of action, Euphyllin should not be taken without the consent of a doctor.
Who is the reception shown to
Euphyllin is used in the presence of the following indications:
- bronchial asthma;
- sleep apnea;
- cerebrovascular insufficiency of the brain;
- emphysema of the lungs;
- broncho-obstructive syndrome;
- pulmonary hypertension;
- left ventricular failure;
- chronic cor pulmonale.
The pharmacological product is included in the patient’s medical complex for congestion in the lungs, hypertensive crisis, ischemia. In rare cases, Euphyllin is used in the treatment of apnea in a newborn child.
A weighty reason for refusing Euphyllin is:
- hypersensitivity to the components of the composition and xanthine derivatives;
- damage to the retina;
- gastritis, peptic ulcer in the acute phase;
- hemorrhagic stroke;
- blood poisoning;
- hypertrophic cardiomyopathy with obstruction;
- blood pressure surges;
- heart rhythm disorder.
Restrictions on taking Euphyllin may affect pregnant women, the elderly, patients with a history of partial liver and kidney dysfunction.
The risk of adverse reactions when taking Euphyllin increases if an intravenous compound was administered to a patient who is less than 14 years old. Euphyllin in tablet form is not prescribed for babies under 6 years old.
Mechanism of action
Euphyllin affects the body as follows:
- slows down the production of phosphodiesterase;
- promotes the accumulation of adenosine monophosphate;
- reduces the permeability of cell membranes;
- prolongs mucociliary clearance;
- stabilizes coronary blood flow.
Additional bonuses of Euphyllin include a stimulating effect on the work of the heart, peripheral venodilatory and urinary effects. Thanks to Euphyllin , blood circulation in the kidneys is normalized, the stability of red blood cells increases, and the acidity of the gastric composition is stabilized. If the patient is prescribed a high dose of Euphyllin, an enileptogenic effect is observed.
With regular use of the drug, the functionality of the respiratory and intercostal muscles increases. Euphyllin is a diuretic, due to which the bile ducts expand, the process of thrombus formation slows down. Euphyllin is absorbed in the gastrointestinal tract. If the medicine was taken after a meal, the absorption rate will be reduced. The maximum concentration of Euphyllin is recorded after 1-2 hours. The bioavailability of the active ingredients of this drug is 90-100%.
One Euphyllin tablet consists of 150 mg of the active ingredient. Additional ingredients of this preparation include potato starch and calcium stearic acid. Euphyllin’s injection solution contains 24 mg / ml aminophylline. In this case, water for injection becomes the only auxiliary substance of the drug.
Solution for injection Euphyllin
Eufillin is sold in the form of pills, which are characterized by a flat-cylindrical round shape and white color. One contour package can contain 10 tablets, a polymer can contains 30 pills. The injection solution is placed in ampoules (5 and 10 ml). You can buy Euphyllin at the pharmacy by providing a prescription from your doctor. The shelf life of the drug is 5 years. The date of manufacture is indicated on the cardboard box in which Euphyllin is placed. The storage temperature should not exceed +20 degrees Celsius.
The order of admission, dosage and duration of treatment with Euphyllin is determined by the doctor. In doing so, he takes into account the exact cause of the ailment, general condition and individual characteristics of the patient. The therapy carried out by means of Euphyllin tablets should last several months. The risk of adverse reactions in a patient increases when Euphyllin is combined with the following drugs:
- beta adrenostimulants;
- hormonal agents;
- drugs that excite the central nervous system;
- agents with anesthetic properties.
By combining Euphyllin and enterosorbents, it is possible to provoke a decrease in the absorption of aminophylline. When taking Rifampicin, Moracizin, Phenobarbital, Carbamazepine, the doctor increases the single dosage of the drug Euphyllin.
When taking (administering) the drug, the patient should limit the use of drinks and products containing caffeine. Otherwise, the likelihood of problems when driving and performing official duties increases. Euphyllin tablets should be drunk 60-90 minutes after a meal. The daily rate is increased every 3 days.
Euphyllin, produced in the form of an injection solution, is used as a composition for electrophoresis, droppers and inhalation. In any case, Euphyllin is administered, guided by the recommendations of the attending physician and the manufacturer’s instructions, prescribed in the official annotation. Instructions for use are in the package with Euphyllin.
If there are contraindications to taking Euphyllin, modern substitutes are prescribed. They can be structural and functional. The first are such drugs as Eufillin-Darnitsa, Aminophyllin-Eskom and Eufillin-farm. The second category contains analogues such as Diprofillin, Theophylline, Neo-Teofedrin, Teofedrin-N, Neoteopek A, Teotard, Theobiolong, Theobromine.
Euphyllin can provoke disturbances in the work of vital organs:
- CNS – loss of orientation in space, tremor of the limbs, severe headache, unreasonable anxiety, problems with sleep.
- Gastrointestinal tract – decreased appetite, dyspepsia, exacerbation of ulcers, upset stools, gastroesophageal reflux.
- Organs of the cardiovascular system – heart palpitations, decreased blood pressure, cardialgia.
In this list, there is a rash, hyperthermia, itching, painful sensations in the chest, excessive sweating, albuminuria, diuresis.
To improve the well-being of the patient taking Euphyllin, detoxification is required. For this, the patient is prescribed forced diuresis. In especially severe cases, plasmapheresis, hemodialysis, hemosorption and peritoneal dialysis are used. With spasms, intramuscular and intravenous injections of Diazepam help. It is strictly forbidden to use drugs from the group of barbiturates simultaneously with Euphyllin.
When using Euphyllin in the form of an injection solution, the intensity of clinical symptoms increases significantly. The higher the dose, the worse the patient’s condition. An overdose of Euphyllin is evidenced by the appearance of diarrhea, convulsive syndrome, severe vomiting, photophobia, hyperemia of the skin. The list is supplemented by overexcitation and arrhythmia. In the absence of symptomatic therapy, a lethal outcome is possible.
The deterioration in general health after taking Euphyllin is evidenced by the appearance of such negative consequences as:
- renal failure;
- skeletal muscle necrosis;
- metabolic acidosis.
Before the arrival of an ambulance, it is necessary to flush the stomach and take medications that have laxative and adsorbing properties. These procedures are often done at home.
If Eufillin is used in parallel with alcohol, the rate and completeness of absorption of the active substance increase. Euphyllin is usually not prescribed during pregnancy, the trimester does not matter. Otherwise, the danger to the fetus increases. The decision to take this medication is made by assessing the possible harm and expected benefits.
Euphyllin and drugs similar to it should be drunk in full accordance with the prescribed therapeutic regimen.